A toxic metabolite of benzene; formed via hepatic metabolism of benzene to 1

1,4-Benzoquinone – 100 g

Brand:
Cayman
CAS:
106-51-4
Storage:
-20
UN-No:
Limited Quantity - 2587 / 6.1

1,4-Benzoquinone is a toxic metabolite of benzene.{47532} It is formed via hepatic metabolism of benzene to 1,4-hydroquinone followed by myeloperoxidase processing of 1,4-hydroquinone in bone marrow.{47533} 1,4-Benzoquinone decreases levels of cytochrome P450 in a concentration-dependent manner in minipig liver microsomes.{47532} It induces DNA mutations in human W138-VA13 and mouse HL18 cells.{47534} 1,4-Benzoquinone (10 and 20 μM) disrupts mitochondrial membrane potential and reduces viability, increases production of reactive oxygen species (ROS), and induces apoptosis in a concentration-dependent manner in HL-60 cells.{47535}  

 

Available on backorder

Add to quotes
SKU: 27560 - 100 g Category:

Description

A toxic metabolite of benzene; formed via hepatic metabolism of benzene to 1,4-hydroquinone followed by myeloperoxidase processing of 1,4-hydroquinone in bone marrow; decreases levels of cytochrome P450 in a concentration-dependent manner in minipig liver microsomes; induces DNA mutations in human W138-VA13 and mouse HL18 cells; disrupts mitochondrial membrane potential at 10 and 20 μM and reduces viability, increases production of ROS, and induces apoptosis in a concentration-dependent manner in HL-60 cells

Formal name: 2,5-cyclohexadiene-1,4-dione

Synonyms:  p-Benzoquinone|p-Quinone|NSC 36324

Molecular weight: 108.1

CAS: 106-51-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Toxicology|Cell Health & Viability|Mitochondrial (dys)Function||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

Related products

  • A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state; activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM

    SC-1 – 10 mg

    The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.  

     

    Brand:
    Cayman
    SKU:10009557 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 500 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 500 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 10 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 50 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 50 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page