13

13,14-dihydro Prostaglandin E1 – 1 mg

Brand:
Cayman
CAS:
19313-28-1
Storage:
-20
UN-No:
De Minimis - 1231 / 3

13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound.{4168,182} It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively.{1607} 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 (Item No. 13010) which has an IC50 value of 40 nM.{960} Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hybrid cells with a Kact value of 668 nM.{1926}  

 

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Description

13,14-dihydro PGE1 is a biologically active metabolite of PGE1 with comparable potency to the parent compound.{4168,182} It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively.{1607} 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 of 40 nM.{960} Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hybrid cells with a Kact of 668 nM.{1926}

Formal name: 9-oxo-11α,15S-dihydroxy-prostan-1-oic acid

Synonyms:  13,14-dihydro PGE1|PGE0

Molecular weight: 356.5

CAS: 19313-28-1

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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