Description
An analog of PGE1
Formal name: 9-oxo-11α,15S-dihydroxy-16,16-difluoro-prostan-1-oic acid
Synonyms: 15-hydroxy Lubiprostone
Molecular weight: 392.5
CAS: 475992-30-4
Purity: ≥98%
Formulation: A solution in methyl acetate
13,14-dihydro-16,16-difluoro Prostaglandin E1 – 500 µg
Brand:
Cayman
CAS:
475992-30-4
Storage:
-20
UN-No:
De Minimis - 1231 / 3
Prostaglandin E1 (PGE1) is produced by the metabolism of dihomo-γ-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1 inhibits platelet aggregation (IC50 = 40 nM){960,4165} and increases vasodilation. 13,14-dihydro-16,16-difluoro PGE1 is an analog of PGE1. 13,14-dihydro PGE1 is a biologically active metabolite of PGE1, inhibiting platelet aggregation with comparable potency to the parent compound.{2126,4165} The addition of two electron-withdrawing fluorine atoms, which should stabilize the molecule against hydrolytic cleavage, may be expected to delay degradation in vivo.{17623}
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