The metabolism of F series prostaglandins (PGs), including PGF1α and PGF2α, commonly begins with the reduction of the double bond between C-13 and C-14 and oxidation of the hydroxyl group at C-15, producing 13,14-dihydro-15-keto PGs. The removal of four carbons at the α-terminus and oxidation of the terminal ω carbon produces the abundant urinary metabolites, including tetranor-PGFM.{2128,2129,2130,2131} 13,14-dihydro-15-keto tetranor PGF1α is a potential metabolite of either PGF1α or PGF2α and likely precursor to tetranor-PGFM.
A potential metabolite of either PGF1α or PGF2α and likely precursor to tetranor-PGFM
Formal name: 9α,11α-dihydroxy-15-oxo-2,3,4,5-tetranor prostanoic acid
Synonyms:
Molecular weight: 300.4
CAS: 24379-94-0
Purity: ≥98%
Formulation: A solution in ethanol
Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway
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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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