Description
A monohydroperoxy PUFA produced from arachidonic acid by 12-LO
Formal name: 12S-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
Synonyms:
Molecular weight: 336.5
CAS: 71774-10-2
Purity: ≥98%
Formulation: A solution in ethanol
12(S)-HpETE – 100 µg
Brand:
Cayman
CAS:
71774-10-2
Storage:
-80
UN-No:
De Minimis - 1170 / 3
12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid.{452,3959} It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4 (LTB4), and 5(S),12(S)-DiHETE.{452} Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids.{194} 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction.{6182,4194} It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons{624} and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.{2366,624}
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