1,2,3-Tristearoyl glycerol-d105 is intended for use as an internal standard for the quantification of 1,2,3-tristearoyl glycerol (Item No. 23335) by GC- or LC-MS. 1,2,3-Tristearoyl glycerol is a triacylglycerol that contains stearic acid (Item No. 10011298) at the sn-1, sn-2, and sn-3 positions. It has been found in beef fat and fully hydrogenated soybean, rapeseed, cottonseed, and palm oils.{54012} 1,2,3-Tristearoyl glycerol has been used to form the lipid matrices of solid lipid nanoparticles.{37243} Formulations containing 1,2,3-tristearoyl glycerol have been used as skin conditioners and thickening agents in cosmetics.
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An internal standard for the quantification of 1,2,3-tristearoyl glycerol by GC- or LC-MS
Formal name: octadecanoic-d35 acid, 1,2,3-propanetriyl ester
Synonyms: Glycerol Trioctadecanoate-d105|TG(18:0/18:0/18:0)-d105|Trioctadecanoyl Glycerol-d105|Tristearin-d105
Molecular weight: 997.1
CAS: 125941-88-0
Purity: ≥99% deuterated forms (d1-d105)
Formulation: A crystalline solid
The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}
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The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
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1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
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