1,2,3-Tristearoyl glycerol-d105 is intended for use as an internal standard for the quantification of 1,2,3-tristearoyl glycerol (Item No. 23335) by GC- or LC-MS. 1,2,3-Tristearoyl glycerol is a triacylglycerol that contains stearic acid (Item No. 10011298) at the sn-1, sn-2, and sn-3 positions. It has been found in beef fat and fully hydrogenated soybean, rapeseed, cottonseed, and palm oils.{54012} 1,2,3-Tristearoyl glycerol has been used to form the lipid matrices of solid lipid nanoparticles.{37243} Formulations containing 1,2,3-tristearoyl glycerol have been used as skin conditioners and thickening agents in cosmetics.
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An internal standard for the quantification of 1,2,3-tristearoyl glycerol by GC- or LC-MS
Formal name: octadecanoic-d35 acid, 1,2,3-propanetriyl ester
Synonyms: Glycerol Trioctadecanoate-d105|TG(18:0/18:0/18:0)-d105|Trioctadecanoyl Glycerol-d105|Tristearin-d105
Molecular weight: 997.1
CAS: 125941-88-0
Purity: ≥99% deuterated forms (d1-d105)
Formulation: A crystalline solid
1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
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1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
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Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}
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1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
Available on backorder