An isomer of LTB4 which would not be expected to occur in either non-enzymatic hydrolysis products

12-epi Leukotriene B4 – 25 µg

Brand:
Cayman
CAS:
83709-73-3
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase.{2784} Compared to LTB4, 12-epi LTB4 has significantly reduced activity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM),{11164} and on guinea pig lung membranes with a (Ki of 4.7 mM).{11162} 12-epi LTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor.{9270}  

 

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Description

An isomer of LTB4 which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase; has significantly reduced activity compared to LTB4

Formal name: 5S,12S-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid

Synonyms:  12-epi LTB4

Molecular weight: 336.5

CAS: 83709-73-3

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Leukotrienes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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