Phosphatidic acids (PAs) can be formed by the acylation of lysophosphatidic acids, the phosphorylation of diacylglycerols, or the removal of the choline group from phosphatidylcholine.{8642} They have important roles in intracellular and extracellular signaling.{3500,18950} 1,2-Dilauroyl-sn-glycero-3-phosphate is a phospholipid containing the medium-chain (12:0) lauric acid inserted at the sn-1 and sn-2 positions. It may be useful in evaluating the role of PAs in micelles, liposomes, and artificial membranes.
A phospholipid containing the medium-chain (12:0) myristic acid inserted at the sn-1 and sn-2 positions
Formal name: 1,2-dilauroyl-sn-glycero-3-phosphatidic acid, monosodium salt
Synonyms: 1,2-Dilauroyl-sn-glycero-3-phosphatidic Acid|1,2-DLPA
Molecular weight: 558.7
CAS: 108321-06-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Lipids|Glycerophospholipids||Research Area|Lipid Biochemistry|Glycerophospholipids
The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}
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