Description
11β-HSD2 plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11β-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess.{11854} 11β-HSD2 mRNA and protein are expressed in placenta and mineralocorticoid target tissues, particularly the kidney.{12000} In mouse, expression of this enzyme is tissue-specific and developmentally regulated, indicating the importance of the enzyme in controlling glucocorticoid-mediated maturation.{11999} Cayman’s 11β-HSD2 Polyclonal Antibody can be used for Western blotting and immunohistochemical analysis of 11β-HSD2 from samples of human, rat, and mouse. The antibody detects a band at 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells.
Synonyms: 11β-HSD2|Corticosteroid 11β-Dehydrogenase Isozyme 2
Immunogen: Synthetic peptide from the N-terminal region of human 11β-HSD2
Formulation: 500 µl of peptide affinity-purified polyclonal antibody
Isotype:
Applications: IHC and WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension
