A metal chelator and inhibitor of metalloproteases; inhibits zinc-dependent hydrolysis of Fa-Gly-Leu-NH2 by B. subtilis neutral protease and B. thermoproteolyticus thermolysin; fungistatic against P. verrucosa (MIC = 0.8 μg/ml); inhibits zinc-induced P. verrucosa metallo-type peptidase activity; induces uncoupling of and inhibits egg production by adult S. mansoni worm pairs from 0.5-150 μM; reduces worm burden in a mouse model of S. mansoni infection at 20 mg/kg per day

1,10-Phenanthroline (hydrate) – 25 g

Brand:
Cayman
CAS:
5144-89-8
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

1,10-Phenanthrine is a metal chelator and inhibitor of metalloproteases.{48730,48731,48732} It inhibits zinc-dependent hydrolysis of Fa-Gly-Leu-NH2 by B. subtilis neutral protease and B. thermoproteolyticus thermolysin.{48730} 1,10-Phenanthrine is fungistatic against P. verrucosa (MIC = 0.8 μg/ml) and inhibits zinc-induced P. verrucosa metallo-type peptidase activity in a concentration-dependent manner.{48731} It induces uncoupling of and inhibits egg production by adult S. mansoni worm pairs in vitro when used at concentrations ranging from 0.5 to 150 μM.{48732} 1,10-Phenanthrine (20 mg/kg per day) reduces worm burden in a mouse model of S. mansoni infection.  

 

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SKU: 28951 - 25 g Category:

Description

A metal chelator and inhibitor of metalloproteases; inhibits zinc-dependent hydrolysis of Fa-Gly-Leu-NH2 by B. subtilis neutral protease and B. thermoproteolyticus thermolysin; fungistatic against P. verrucosa (MIC = 0.8 μg/ml); inhibits zinc-induced P. verrucosa metallo-type peptidase activity; induces uncoupling of and inhibits egg production by adult S. mansoni worm pairs from 0.5-150 μM; reduces worm burden in a mouse model of S. mansoni infection at 20 mg/kg per day

Formal name:

Synonyms:  o-Phenanthroline

Molecular weight: 198.2

CAS: 5144-89-8

Purity: ≥98%

Formulation: A solid

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