11-deoxy PGE1 is a synthetic analog of PGE1. Early reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2.{1360

11-deoxy Prostaglandin E1 – 5 mg

Brand:
Cayman
CAS:
37786-00-8
Storage:
-20
UN-No:
Non-Hazardous - /

11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1. Early reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2.{1360,1026} However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC50 of 0.25 µM.{2120} 11-deoxy PGE1 also exhibits vasodepressor and bronchodilator responses in guinea pigs.{2217} 11-deoxy PGE1 exhibits selectively for the mouse EP3 receptor and is essentially equipotent to PGE1 at this receptor subtype. The Ki values for binding to the mouse EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively.{6640}  

 

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11-deoxy PGE1 is a synthetic analog of PGE1. Early reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2.{1360,1026} However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC50 of 0.25 µM.{2120} 11-deoxy PGE1 also exhibits vasodepressor and bronchodilator responses in guinea pigs.{2217} 11-deoxy PGE1 exhibits selectively for the mouse EP3 receptor and is essentially equipotent to PGE1 at this receptor subtype. The Ki values for binding to the murine EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively.{6640}

Formal name: 9-oxo-15S-hydroxy-prost-13E-en-1-oic acid

Synonyms:  11-deoxy PGE1

Molecular weight: 338.5

CAS: 37786-00-8

Purity: ≥96%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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