An endogenous mineralocorticoid; a metabolite of progesterone and precursor to aldosterone and corticosterone; metabolized to the neuroactive compound THDOC

11-deoxy Corticosterone – 50 mg

Brand:
Cayman
CAS:
64-85-7
Storage:
-20
UN-No:
Non-Hazardous - /

11-deoxy Corticosterone (DOC) is an endogenous mineralocorticoid synthesized in the zona fasciculata and zona glomerulosa of the adrenal gland.{41026} It is a metabolite of progesterone (Item No. 15876) and precursor to aldosterone (Item No. 15273) and corticosterone (Item No. 16063).{41025} DOC is metabolized to the neuroactive compound (3α,5α)-2,21-dihydroxypregnan-20-one (THDOC), which positively modulates GABAA receptors and produces effects similar to barbiturates in rats.{41027} Injections of naloxone (Item Nos. 15594 | ISO60191) and corticotropin-releasing hormone (CRH) increase, while dexamethasone decreases, DOC in cynomolgus monkeys.{41026} DOC levels are increased 3.4-fold in obese and diabetic mice.{41025}  

 

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SKU: 22916 - 50 mg Category:

Description

An endogenous mineralocorticoid; a metabolite of progesterone and precursor to aldosterone and corticosterone; metabolized to the neuroactive compound THDOC, which positively modulates GABAA receptors and produces effects similar to barbiturates in rats; levels increase following naloxone or CRH injection in cynomolgus monkeys; levels decrease following dexamethasone administration; increased 3.4-fold in obese and diabetic mice

Formal name: 21-hydroxy-pregn-4-ene-3,20-dione

Synonyms:  21-hydroxy Progesterone|DOC|NSC 11319

Molecular weight: 330.5

CAS: 64-85-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Neuroscience|Neuroendocrinology

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