An inverse agonist of opsin; isomerizes to all-trans retinal to start the phototransduction cycle of mammalian vision; binds as a partial agonist to a G121L-mutated opsin; application to compound eyes restored moth visual sensitivity almost completely

11-cis Retinal – 1 mg

Brand:
Cayman
CAS:
564-87-4
Storage:
-80
UN-No:
De Minimis - 1114 / 3

11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin.{29223} When 11-cis retinal absorbs a photon of light, it isomerizes to form all-trans retinal (Item No. 18449) beginning the phototransduction cycle, which is the basis for mammalian vision. A G121L mutation in opsin allows 11-cis retinal to bind as a partial agonist and activate rhodopsin in the absence of light.{38067} In a moth model of carotenoid deficiency-induced low visual sensitivity, 11-cis retinal application to compound eyes restored visual sensitivity almost completely.{38066}  

 

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Description

An inverse agonist of opsin; isomerizes to all-trans retinal to start the phototransduction cycle of mammalian vision; binds as a partial agonist to a G121L-mutated opsin; application to compound eyes restored moth visual sensitivity almost completely,

Formal name: 11-cis-retinal

Synonyms:  11-cis Retinaldehyde|11-cis Vitamin A aldehyde

Molecular weight: 284.4

CAS: 564-87-4

Purity: ≥65%

Formulation: A solution in benzene

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Ophthalmology

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