An internal standard for the quantification of 11β-PGF2α by GC- or LC-MS

11β-Prostaglandin F2α-d4 – 50 µg

Brand:
Cayman
CAS:
1240398-18-8
Storage:
-20
UN-No:
Non-Hazardous - 1170 / 3

11β-Prostaglandin F2α-d4 (11β-PGF2α-d4) is intended for use as an internal standard for the quantification of 11β-PGF2α (Item No. 16520) by GC- or LC-MS. 11β-PGF2α is the primary metabolite of PGD2 (Item No. 12010).{57057} It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase (PGFS; Item No. 10007940) in the liver or lung.{57058} 11β-PGF2α induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF2α (FP) receptors, with an EC50 value of 0.045 µM.{57057} It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 µM.{1756} 11β-PGF2α (0.1 and 1 µM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 µM.{57059}  

 

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SKU: 10008989 - 50 µg Category:

Description

An internal standard for the quantification of 11β-PGF2α by GC- or LC-MS

Formal name: 9α,11β,15S-trihydroxy-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid

Synonyms:  11-epi PGF2α-d4|11β-PGF2α-d4|9α,11β-PGF2α-d4

Molecular weight: 358.5

CAS: 1240398-18-8

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solution in ethanol

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology

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