11β-13,14-dihydro-15-keto PGF2α is a metabolite of PGD2 (Item No. 12010) in the 15-hydroxy PGDH pathway.{11174,11176} Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF2α in the plasma within 10 minutes.{11174} Homogenates of human lung metabolize PGD2 first to 11β-PGF2α and then to 11β-15-keto-PGF2α in the presence of NAD+, but not 11β-13,14-dihydro-15-keto PGF2α.{11176} Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF2α, via 11β-PGF2α, in the presence of NAD+ and NADP+.{11176}
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A metabolite of PGD2; appears in plasma of normal males within 10 minutes of tritiated PGD2 infusion or inhalation
Formal name: 9α,11β-dihydroxy-15-oxo-prost-5Z-en-1-oic acid
Synonyms: 11-epi-13,14-dihydro-15-keto PGF2α|11β-13,14-dihydro-15-keto PGF2α
Molecular weight: 354.5
CAS: 107615-77-0
Purity: ≥95%
Formulation: A solution in methyl acetate
Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway
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