A natural alkaloid that blocks potently inhibits MEK-1 (IC50 = 9 nM); also inhibits numerous kinases in vitro

10Z-Hymenialdisine – 500 µg

Brand:
Cayman
CAS:
82005-12-7
Storage:
-20
UN-No:
De Minimis - 2810 / 6.1

10Z-Hymenialdisine is a natural marine sponge alkaloid with numerous cellular actions. Most notably, it blocks signaling through the Raf-1/MEK-1/MAPK pathway by potently inhibiting MEK-1 (IC50 = 9 nM).{24027} Hymenialdisine also inhibits numerous kinases in vitro, most notably GSK3β, CDK1/cyclin B, CDK5/p25, CK1, and CDK2/cyclin E (IC50s = 10, 22, 28, 35, and 40 nM, respectively), as well as, less potently, ERK1/2 and several isoforms of PKC.{28027,24024} Early studies demonstrated that it suppresses inflammatory gene expression by blocking signaling through NF-κB at micromolar concentrations.{28028} At similar concentrations, hymenialdisine also blocks bacterial quorum sensing.{28029}  

 

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Description

A natural alkaloid that blocks potently inhibits MEK-1 (IC50 = 9 nM); also inhibits numerous kinases in vitro, most notably GSK3β, CDK1/cyclin B, CDK5/p25, CK1, and CDK2/cyclin E (IC50s = 10, 22, 28, 35, and 40 nM, respectively), as well as, less potently, ERK1/2, several isoforms of PKC, and NF-κB

Formal name: (4Z)-4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-pyrrolo[2,3-c]azepin-8(1H)-one

Synonyms: 

Molecular weight: 324.1

CAS: 82005-12-7

Purity: ≥97%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Kinase Inhibitors|CK1||Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Quorum Sensing

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