A DHA metabolite

10(S),17(S)-DiHDHA – 25 µg

Brand:
Cayman
CAS:
871826-47-0
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities.{14974,14973,14972} 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX).{19393} It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA.{14974,19393} It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse.{14974} It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation.{19393,19394}  

 

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SKU: 10008128 - 25 µg Category:

Description

A DHA metabolite, also referred to as protectin DX (PDX), produced by an apparent double lipoxygenase-mediated reaction; blocks neutrophil infiltration in mouse peritonitis by 20-25% at a dose of 1 ng/mouse; inhibits platelet activation by both impairing TX synthesis and TX receptor activation

Formal name: 10(S),17(S)-dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid

Synonyms:  10(S),17(S)-DiHDoHE|PDX|Protectin DX

Molecular weight: 360.5

CAS: 871826-47-0

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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