Nitration product of oleic acid in vivo mediated by peroxynitrite

10-Nitrooleate – 100 µg

Brand:
Cayman
CAS:
875685-46-4
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate (LNO2; Item No. 10037), cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide.{11912,13284,13287,13288} 10-Nitrooleate is one of two regioisomers of nitrooleate, the other being 9-nitrooleate (Item No. 10008042) (OA-NO2; used for the mixture of isomers), which are formed by nitration of oleic acid in approximately equal proportions in vivo.{14255} Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H2O2 and nitrite, all mediate the nitration of oleic acid. OA-NO2 is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 ± 52 nM and 302 ± 369 nM, respectively. OA-NO2 activates PPARγ approximately 7-fold at a concentration of 1 µM and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 µM.{14255}  

 

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SKU: 10008043 - 100 µg Category:

Description

Nitration product of oleic acid in vivo mediated by peroxynitrite, acidified nitrite, or myeloperoxidase (in the presence of H2O2 and nitrite)

Formal name: 10-nitro-9E-octadecenoic acid

Synonyms:  10-nitro-9-trans-Octadecenoic Acid|10-Nitrooleic Acid

Molecular weight: 327.5

CAS: 875685-46-4

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Fatty Acids||Product Type|Biochemicals|Lipids|Octadecanoids||Product Type|Biochemicals|Ox Stress Reagents|NO Donors||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Oxidative Stress & Reactive Species|Protein Oxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Myeloperoxidase

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