The product of nitration of linoleate by NO-derived reactive species; activates PPARγ (Ki = 133 nM)

10-Nitrolinoleate – 100 µg

Brand:
Cayman
CAS:
774603-04-2
Storage:
-20
UN-No:
De Minimis - 1170 / 3

10-Nitrolinoleate is the product of nitration of linoleate by NO-derived reactive species.{25769,11912} Other nitrolinoleates detected in human plasma and urine include 9-, 12-, and 13-nitrolinoleate.{25770} Nitrolinoleates activate peroxisome proliferator-activated receptor γ (PPARγ; Ki = 133 nM), inducing CD36 expression in macrophages, adipocyte differentiation, and glucose uptake.{14255,13284} Nitrolinoleates can also be metabolized by smooth muscle cells to produce nitrite derivatives which in turn form NO, leading to increased cGMP production and smooth muscle relaxation.{11912,13287} Through the same mechanism, nitrolinoleate-derived NO suppresses leukocyte adhesion, in part through nitrosation of CD40.{25768} Alteratively, nitrolinoleates can act independently of NO/cGMP and PPARγ signaling to suppress neutrophil and macrophage functions.{25769,25770,14473}  

 

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SKU: 10037 - 100 µg Category:

Description

The product of nitration of linoleate by NO-derived reactive species; activates PPARγ (Ki = 133 nM), inducing CD36 expression in macrophages, adipocyte differentiation, and glucose uptake; can also be metabolized to produce nitrite derivatives which in turn form NO, leading to increased cGMP production

Formal name: 10-nitro-9E,12Z-octadecadienoic acid

Synonyms:  10-nitro-9,12-Octadecadienoic Acid|LNO2

Molecular weight: 325.4

CAS: 774603-04-2

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Octadecanoids||Product Type|Biochemicals|Ox Stress Reagents|NO Donors||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Fatty Acids||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen

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