An inhibitor of microtubule assembly (IC50s = 23 and 0.9 µM for porcine brain and Physaram microtubules

10-Deacetylbaccatin III – 10 mg

Brand:
Cayman
CAS:
32981-86-5
Storage:
-20
UN-No:
Non-Hazardous - /

10-Deacetylbaccatin III is an inhibitor of microtubule assembly (IC50s = 23 and 0.9 µM for porcine brain and Physaram microtubules, respectively) found in T. baccata extracts.{37074} It is a precursor in the semisynthetic synthesis of paclitaxel (Item No. 10461) and other semisynthetic toxoids.{37075} 10-Deacetylbaccatin III also selectively inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM), while having no effect on macrophage morphology.{37076}  

 

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Description

An inhibitor of microtubule assembly (IC50s = 23 and 0.9 µM for porcine brain and Physaram microtubules, respectively); a precursor in the semisynthetic synthesis of paclitaxel; inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM)

Formal name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one

Synonyms:  NSC 251677

Molecular weight: 544.6

CAS: 32981-86-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Natural Products||Research Area|Cancer||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Parasitic Diseases|Leishmaniasis

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