A lysolipid derivative of glucocerebroside; a fully synthetic 1-β-D-glucosylsphingosine

1-β-D-Glucosylsphingosine (d18:1) – 5 mg

Brand:
Cayman
CAS:
52050-17-6
Storage:
-20
UN-No:
Non-Hazardous - /

1-β-D-Glucosylsphingosine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucocerebrosides (Item No. 23207).{41130} They are formed when sphingosines undergo glucosidation by UDP-glucose.{41131} Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher’s disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3); thus, glucosylsphingosine has been used as a key biomarker of the disease.{41130,41132} This product is a fully synthetic 1-β-D-glucosylsphingosine. [Matreya, LLC. Catalog No. 2086]  

 

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Description

A lysolipid derivative of glucocerebroside; a fully synthetic 1-β-D-glucosylsphingosine

Formal name: 2S-amino-3R-hydroxy-4E-octadecen-1-yl β-D-glucopyranoside

Synonyms:  1-β-D-Glucosylsphingosine (synthetic)|Glucosyl-C18-Sphingosine|Glucosylsphingosine (d18:1)

Molecular weight: 461.6

CAS: 52050-17-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience

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