Potently activates PKCα

1-Stearoyl-2-Arachidonoyl-sn-Glycerol – 5 mg

Brand:
Cayman
CAS:
65914-84-3
Storage:
-80
UN-No:
De Minimis - 1231 / 3

Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid to phosphorylate target proteins and they initiate a variety of important signalling cascades.{943} 1-Stearoyl-2-arachidonoyl-sn-glycerol (SAG) is a DAG that contains the ω-6 polyunsaturated fatty acid arachidonic acid in the sn-2 position and stearic acid in the sn-1 position of the glycerol backbone. It can potently activate PKCα, PKCε, and PKCδ at nM concentrations.{15530} Independent of PKC signalling, SAG competitively binds to the Ras activator RasGRP with a Ki value of 4.49 µM in Jurkat T-cells.{15529}  

 

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SKU: 10008650 - 5 mg Category:

Description

Potently activates PKCα, PKCε, and PKCδ at nM concentrations; competitively binds to the Ras activator RasGRP (Ki = 4.49 µM) in Jurkat-T cells

Formal name: 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol

Synonyms:  SAG

Molecular weight: 645

CAS: 65914-84-3

Purity: ≥95%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Glycerolipids||Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Lipid Biochemistry|Glycerolipids

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