A degradation product and potential impurity in commercial ibuprofen preparations

1-oxo Ibuprofen – 5 mg

Brand:
Cayman
CAS:
65813-55-0
Storage:
-20
UN-No:
Non-Hazardous - /

1-oxo Ibuprofen is a degradation product and potential impurity in commercial preparations of ibuprofen.{38075,38073} Ibuprofen (Item No. 70280) is a non-selective, reversible COX inhibitor and non-steroidal anti-inflammatory drug (NSAID).{38075} Formulations containing ibuprofen are widely used for inflammation, pain, and fever. However, it is considered, among other pharmaceuticals, an environmental contaminant because it cannot be completey biodegraded during the wastewater treatment process.{38074} Degradation using ultraviolet light, Fe(III), and peroxymonosulfate has been described and results in degradation products, including 1-oxo ibuprofen.{38075}  

 

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Description

A degradation product and potential impurity in commercial ibuprofen preparations,

Formal name: α-methyl-4-(2-methyl-1-oxopropyl)-benzeneacetic acid

Synonyms:  Ibuprofen Impurity J

Molecular weight: 220.3

CAS: 65813-55-0

Purity: ≥98%

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Pharmaceutical Impurities||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Pain Research||Research Area|Toxicology|Environmental|Aquatic Systems

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