1-Myristoyl-rac-glycerol is a monoacylglycerol that contains myristic acid (Item No. 13351) at the sn-1 position. It is active against H. pylori with a 50% bactericidal concentration (BC50) value of 0.3 mM.{45619} 1-Myristoyl-rac-glycerol is cytotoxic to A498, PaCa-2, and PC3 cancer cells (EC50s = 3.58, 1.87, and 8.84 µg/ml, respectively).{45620} It has been found in saw palmetto berries.
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A monoacylglycerol; active against H. pylori (BC50 = 0.3 mM); cytotoxic to A498, PaCa-2, and PC3 cancer cells (EC50s = 3.58, 1.87, and 8.84 µg/ml, respectively); has been found in saw palmetto berries
Formal name: tetradecanoic acid, 2,3-dihydroxypropyl ester
Synonyms: 1-Monomyristin|MG(14:0/0:0/0:0)
Molecular weight: 302.5
CAS: 589-68-4
Purity: ≥98%
Formulation: A solid
The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
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