An inhibitor of IDO (IC50 = 7 µM) that is effective in vivo; prevents T-cell anergy triggered by dendritic cells overexpressing IDO in mice; causes regression of tumors and prolongs survival when used in combination with chemotherapy

1-methyl-D-Tryptophan – 1 g

Brand:
Cayman
CAS:
110117-83-4
Storage:
-20
UN-No:
Non-Hazardous - /

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo.{26962,26961} 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 µM) that is effective in vivo.{26963,26959} In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO.{26959} It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO.{26962,26961} 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival.{26962,26960} Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.{26960}  

 

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Description

An inhibitor of IDO (IC50 = 7 µM) that is effective in vivo; prevents T-cell anergy triggered by dendritic cells overexpressing IDO in mice; causes regression of tumors and prolongs survival when used in combination with chemotherapy

Formal name: 1-methyl-D-tryptophan

Synonyms: 

Molecular weight: 218.3

CAS: 110117-83-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Amino Acid Turnover||Research Area|Cancer||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases

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