A phenazine pigment and virulence factor produced by P. aeruginosa; increases ROS production in RAW 264.7 cells in a concentration-dependent manner; increases release of elastase and MPO by fMLP- and cytochalasin B-activated human neutrophils at ≥1.55 and ≥3.12 μM

1-Hydroxyphenazine – 25 mg

Brand:
Cayman
CAS:
528-71-2
Storage:
-20
UN-No:
Non-Hazardous - /

1-Hydroxyphenazine is a phenazine pigment and virulence factor produced by P. aeruginosa.{42947,42948} It increases production of reactive oxygen species (ROS) in RAW 264.7 cells in a concentration-dependent manner.{42948} 1-Hydroxyphenazine (≥1.55 and ≥3.12 μM) increases release of elastase and myeloperoxidase (MPO), respectively, by human neutrophils activated with N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; Item No. 21495) and cytochalasin B (Item No. 11328).{42947} It reduces ciliary beat frequency in isolated guinea pig tracheal rings, resulting in ciliary dyskinesia by 1 hour when used at concentrations of 10, 50, and 100 μM and ciliary stasis by 5 hours at 50 and 100 μM.{42949} 1-Hydroxyphenazine reduces tracheal mucus velocity in anesthetized guinea pigs when administered as a 100 or 200 ng bolus dose. It is also active against the plant pathogenic fungi F. graminearum, P. grisea, A. solani, F. oxysporium, and S. sclerotiorum (MICs = 2-50 μg/ml).{42950}  

 

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Description

A phenazine pigment and virulence factor produced by P. aeruginosa; increases ROS production in RAW 264.7 cells in a concentration-dependent manner; increases release of elastase and MPO by fMLP- and cytochalasin B-activated human neutrophils at ≥1.55 and ≥3.12 μM, respectively; reduces ciliary beat frequency in isolated guinea pig tracheal rings, resulting in ciliary dyskinesia by 1 hour at 10, 50, and 100 μM and ciliary stasis by 5 hours at 50 and 100 μM; reduces tracheal mucus velocity in anesthetized guinea pigs when administered as a 100 or 200 ng bolus dose; active against the plant pathogenic fungi F. graminearum, P. grisea, A. solani, F. oxysporium, and S. sclerotiorum (MICs = 2-50 μg/ml)

Formal name: 1-phenazinol

Synonyms:  Hemipyocyanine|NSC 88882

Molecular weight: 196.2

CAS: 528-71-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Pesticides|Fungicides||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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