An atypical sphingolipid; contains a double bond at the n-4 (14Z) native position; formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis; is metabolized by CYP4A and CYP4F family enzymes in MEF cells

1-Deoxysphingosine (m18:1(14Z)) – 1 mg

Brand:
Cayman
CAS:
2190487-94-4
Storage:
-20
UN-No:
De Minimis - 1170 / 3

1-Deoxysphingosine (m18:1(14Z)) is an atypical sphingolipid that contains a double bond at the n-4 (14Z) native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.{40307,42289} It lacks the C1-hydroxyl group necessary for canonical degradation, however, it is metabolized by the cytochrome P450 (CYP) subfamilies CYP4A and CYP4F in MEF cells.{42289}  

 

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SKU: 24515 - 1 mg Category:

Description

An atypical sphingolipid; contains a double bond at the n-4 (14Z) native position; formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis; is metabolized by CYP4A and CYP4F family enzymes in MEF cells ,

Formal name: (2S,3R,14Z)-2-amino-14-octadecen-3-ol

Synonyms:  14Z-1-Deoxysphingosine (d18:1)|1-deoxySO

Molecular weight: 283.5

CAS: 2190487-94-4

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Lipid Biochemistry|Sphingolipids

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