A glucose analog that potently inhibits α-glucosidase I and II to prevent the formation of complex N-linked oligosaccharides (IC50= ~2 µM)

1-Deoxynojirimycin (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
73285-50-4
Storage:
-20
UN-No:
Non-Hazardous - /

1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II. It prevents the formation of complex N-linked oligosaccharides in yeast and intact mammalian cells by inhibiting both α-glucosidase I and II with IC50 values of ~2 µM.{16271,16267} The FDA has granted orphan drug designation to dNM (hydrochloride) for the treatment of Pompe disease, an inherited lysosomal storage disorder caused by a mutation that alters the structure and stability of α-glucosidase. 1-dNM, at a concentration of 0.4 mM, also inhibits virus spread in HIV-infected lymphocyte cultures by interfering with α-glucosidase activity.{16269,16270}  

 

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SKU: 10011718 - 10 mg Category:

Description

A glucose analog that potently inhibits α-glucosidase I and II to prevent the formation of complex N-linked oligosaccharides (IC50= ~2 µM)

Formal name: 2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol, monohydrochloride

Synonyms:  1-dNM|Moranoline

Molecular weight: 199.6

CAS: 73285-50-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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