A glucose analog that potently inhibits α-glucosidase I and II to prevent the formation of complex N-linked oligosaccharides (IC50= ~2 µM)

1-Deoxynojirimycin – 50 mg

Brand:
Cayman
CAS:
19130-96-2
Storage:
-20
UN-No:
Non-Hazardous - /

1-Deoxynojirimycin (1-dNM), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II. It prevents the formation of complex N-linked oligosaccharides in yeast and intact mammalian cells by inhibiting both α-glucosidase I and II with IC50 values of ~2 µM.{16271,16267} 1-dNM, at a concentration of 0.4 mM, is reported to inhibit virus spread in HIV-infected lymphocyte cultures by interfering with α-glucosidase activity.{16269,16270}  

 

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Description

A glucose analog that potently inhibits α-glucosidase I and II to prevent the formation of complex N-linked oligosaccharides (IC50= ~2 µM)

Formal name: 2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol

Synonyms:  1-dNM|BAY-h-5955|D-1-Deoxynojirimycin|Moranoline

Molecular weight: 163.2

CAS: 19130-96-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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