A specific inhibitor of class I α-1

1-Deoxymannojirimycin (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
73465-43-7
Storage:
-20
UN-No:
Non-Hazardous - /

1-Deoxymannojirimycin is a specific inhibitor of class I α-1,2-mannosidase (IC50 = 0.02 µM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi and for targeting misfolded proteins for translocation out of the endoplasmic reticulum and degradation by the proteasome.{28144,28145} By inhibiting α-1,2-mannosidase activity, this compound generates N-linked oligosaccharides with high mannose content, preventing misfolded protein degradation. This compound has been used for studies on glycoprotein processing and as a model for the development of anticancer and antiviral therapies.{28146,28147}  

 

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Description

A specific inhibitor of class I α-1,2-mannosidase (IC50 = 20 mM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi; inhibiting α-1,2-mannosidase with 1-Deoxymannojirimycin generates N-linked oligosaccharides with high mannose content, preventing proteasomal degradation of misfolded proteins

Formal name: 2R-(hydroxymethyl)-3R,4R,5R-piperidinetriol, monohydrochloride

Synonyms: 

Molecular weight: 199.6

CAS: 73465-43-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases

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