Inhibits GSK3β more potently (IC50 = 18 nM) than CDK1/cyclin B or CDK5/p25 (IC50s = 2.0 and 4.2 µM

1-Azakenpaullone – 1 mg

Brand:
Cayman
CAS:
676596-65-9
Storage:
-20
UN-No:
Non-Hazardous - /

1-Azakenpaullone is an analog of kenpaullone (Item No. 10010239) that inhibits glycogen synthase kinase 3β (GSK3β) more potently (IC50 = 18 nM) than CDK1/cyclin B or CDK5/p25 (IC50s = 2.0 and 4.2 µM, respectively).{27328} Through its effects on GSK3β, 1-azakenpaullone stimulates the proliferation of human pancreatic islets and drives the differentiation of mouse embryonic stem cells and Nematostella larvae.{27329,27331,27330}  

 

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Description

Inhibits GSK3β more potently (IC50 = 18 nM) than CDK1/cyclin B or CDK5/p25 (IC50s = 2.0 and 4.2 µM, respectively); stimulates the proliferation of human islets and drives the differentiation of mouse embryonic stem cells and Nematostella larvae

Formal name: 9-bromo-7,12-dihydro-pyrido[3′,2′:2,3]azepino[4,5-b]indol-6(5H)-one

Synonyms: 

Molecular weight: 328.2

CAS: 676596-65-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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