A phospholipid; has been found in rat brain as 37% of the arachidonic acid-containing LPA species; a precursor to 1-AG; binds to the LPA2/EDG4 receptor (EC50 = ~10 nM); prevents TNF-α and IL-6 secretion in LPS-stimulated wild-type but not Lpa2-/- dendritic cells; decreases differentiation of HT-29 human colon carcinoma cells to goblet cells

1-Arachidonoyl Lysophosphatidic Acid (ammonium salt) – 500 µg

Brand:
Cayman
CAS:
799268-65-8
Storage:
-20
UN-No:
Non-Hazardous - 1230 / 3|6.1

1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol (1-AG; Item No. 62150).{10322} 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM.{43503} It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS.{43504} It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.{43505}  

 

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SKU: 10019 - 500 µg Category:

Description

A phospholipid; has been found in rat brain as 37% of the arachidonic acid-containing LPA species; a precursor to 1-AG; binds to the LPA2/EDG4 receptor (EC50 = ~10 nM); prevents TNF-α and IL-6 secretion in LPS-stimulated wild-type but not Lpa2-/- dendritic cells; decreases differentiation of HT-29 human colon carcinoma cells to goblet cells

Formal name: (5Z,8Z,11Z,14Z)-eicosatetraenoic acid, (2R)-hydroxy-3-(phosphonooxy)propyl ester, monoammonium salt

Synonyms:  1-Arachidonoyl LPA|1-Arachidonoyl-sn-glycero-3-phosphate|1-Eicosatetraenoyl-sn-glycero-3-PA|20:4 Lyso PA|LPA(20:4)|PA(20:4/0:0)

Molecular weight: 475.6

CAS: 799268-65-8

Purity: ≥95%

Formulation: A solution in H2O:MeOH:NH4OH (41:25:1)

Product Type|Biochemicals|Lipids|Glycerophospholipids||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Lipid Biochemistry|Glycerophospholipids

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