A non-specific CYP inhibitor; acts as a suicide substrate

1-Aminobenzotriazole – 500 mg

Brand:
Cayman
CAS:
1614-12-6
Storage:
-20
UN-No:
Non-Hazardous - /

1-aminobenzotriazole (ABT) is a non-specific cytochrome P450 (CYP) inhibitor.{32434,32435,24115} It does not appear to affect other enzymes, including UDP-glucuronosyltransferases.{32436,20875} ABT acts as a CYP suicide substrate, producing maximal destruction of hepatic and renal microsome CYP protein in vitro at 10 mM.{32436} It is effective in vivo, significantly reducing CYP content in both liver and kidney in rats within two hours.{32436} The effects of ABT on CYP activity is time-dependent, with significant shift in IC50 values with preincubation.{24115}  

 

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Description

A non-specific CYP inhibitor; acts as a suicide substrate, producing maximal destruction of hepatic and renal microsome CYP protein in vitro at 10 mM; effective in vivo, significantly reducing CYP content in both liver and kidney in rats within two hours

Formal name: 1H-benzotriazol-1-amine

Synonyms:  1-Benzotriazolylamine|3-Aminobenzotriazole|ABT|NSC 114498|NSC 656987

Molecular weight: 134.1

CAS: 1614-12-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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