An NMDA receptor antagonist (Ki = 43 nM for inhibition of spermine binding); blocks generalized seizures in a mouse model of epilepsy (ED50 = 0.85 mg/kg); increases horizontal locomotor activity in mice (ED50 = 2.71 mg/kg); decreases immobility time in the tail suspension and forced swim tests in a mouse model of social defeat stress at 0.1 mg/kg; inhibits AChE (Kis = 6.2 and 7.9 μM for electric eel and rat brain AChE

(−)-MK-801 (maleate) – 5 mg

Brand:
Cayman
CAS:
121917-57-5
Storage:
-20
UN-No:
Non-Hazardous - /

(–)-MK-801 is an NMDA receptor antagonist (Ki = 43 nM for inhibition of spermine binding) and an isomer of (+)-MK-801 (Item No. 10009019).{26258} In vivo, (–)-MK-801 blocks generalized seizures in a mouse model of epilepsy (ED50 = 0.85 mg/kg) and increases horizontal locomotor activity in mice (ED50 = 2.71 mg/kg).{45209} (–)-MK-801 (0.1 mg/kg) decreases immobility time in the tail suspension and forced swim tests in a mouse model of social defeat stress, indicating antidepressant-like activity.{45210} (–)-MK-801 also inhibits acetylcholinesterase (AChE) with Ki values of 6.2 and 7.9 μM for electric eel and rat brain AChE, respectively.{45211}  

 

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SKU: 27213 - 5 mg Category:

Description

An NMDA receptor antagonist (Ki = 43 nM for inhibition of spermine binding); blocks generalized seizures in a mouse model of epilepsy (ED50 = 0.85 mg/kg); increases horizontal locomotor activity in mice (ED50 = 2.71 mg/kg); decreases immobility time in the tail suspension and forced swim tests in a mouse model of social defeat stress at 0.1 mg/kg; inhibits AChE (Kis = 6.2 and 7.9 μM for electric eel and rat brain AChE, respectively)

Formal name: (5R,10S)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine, (2Z)-2-butenedioate

Synonyms: 

Molecular weight: 337.4

CAS: 121917-57-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Seizure Disorders

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