An epimer of (−)-EGC and potent antioxidant; significantly inhibits the proliferation of HCT116 and SW480 cancer cells; inhibits the aggregation of amyloid β peptide in vitro (IC50 = 17.5 µM)

(−)-Gallocatechin – 10 mg

Brand:
Cayman
CAS:
3371-27-5
Storage:
-20
UN-No:
Non-Hazardous - /

(−)-Gallocatechin ((−)-GC) is an epimer of (−)-epigallocatechin ((−)-EGC; Item No. 11809). They are flavan-3-ols and members of the catechin family of polyphenolic antioxidants found in green tea and other plant extracts.{23119} Both (−)-GC and (−)-EGC are potent antioxidants and significantly inhibit the proliferation of HCT116 and SW480 cancer cells.{23115,27615,23119} (−)-GC also inhibits the aggregation of amyloid β peptide in vitro (IC50 = 17.5 µM).{27617} With increasing temperature, the steaming of green tea leaves results in the reduction of 2,3-cis isomers, like (−)-EGC, and an increase in 2,3-trans isomers, like (−)-GC.{27615,27616}  

 

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Description

An epimer of (−)-EGC and potent antioxidant; significantly inhibits the proliferation of HCT116 and SW480 cancer cells; inhibits the aggregation of amyloid β peptide in vitro (IC50 = 17.5 µM)

Formal name: (2S,3R)-3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol

Synonyms:  (−)-GC

Molecular weight: 306.3

CAS: 3371-27-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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