An enantiomer of (+)-bicuculline methochloride; increases the firing rate in rat cortical neurons similar to the (+) isomer

(−)-Bicuculline methochloride – 10 mg

Brand:
Cayman
CAS:
53552-05-9
Storage:
-20
UN-No:
De Minimis - 1544 / 6.1

(–)-Bicuculline methochloride is an enantiomer of the GABA antagonist (+)-bicuculline methochloride.{45361} It increases the firing rate in rat cortical neurons similar to the (+) isomer but lacks GABA antagonist activity. (–)-Bicuculline methochloride inhibits sodium-independent GABA receptor binding with an IC50 value of 500 μM, which is approximately 100-fold less potent than (+)-bicuculline methochloride, but there is no stereoselectivity for sodium-dependent GABA receptor binding.{45362}  

 

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SKU: 27802 - 10 mg Category:

Description

An enantiomer of (+)-bicuculline methochloride; increases the firing rate in rat cortical neurons similar to the (+) isomer, but lacks GABA antagonist activity; inhibits sodium-independent GABA receptor binding (IC50 = 500 μM), which is approximately 100-fold less potent than the (+) isomer, but there is no stereoselectivity for sodium-dependent GABA receptor binding

Formal name: (5R)-5-[(6S)-6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium, monochloride

Synonyms: 

Molecular weight: 417.8

CAS: 53552-05-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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