A cyclic analog of L-glutamate; binds to GluK1

(−)-(α)-Kainic Acid (hydrate) – 5 mg

Brand:
Cayman
CAS:
58002-62-3
Storage:
22
UN-No:
Non-Hazardous - /

(−)-(α)-Kainic acid is a cyclic analog of L-glutamate originally isolated from D. simplex that has neuroexcitatory activities.{55282} It binds to the homomeric kainate receptors GluK1, GluK2, GluK3, GluK4, and GluK5 (Kis = 75.9, 12.7, 32.8, 4.7, and 15 nM, respectively).{55283} (−)-(α)-Kainic acid (5 mM) induces calcium influx and membrane depolarization, as well as glutamate release, in rat brain synaptosomes.{55284} It induces chromatin condensation and nuclear membrane fragmentation, markers of apoptosis, in primary neonatal cerebellar granule neurons when used at a concentration of 100 µM.{55285} Intracerebroventricular administration of (−)-(α)-kainic acid induces convulsive behavior in rats (ED50 = 0.51 nmol/animal) and induces seizures in mice with a 50% convulsive dose (CD50) value of 0.39 nmol/animal.{41914} It has been commonly used to induce seizures in rodents.{55286,23784}  

 

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Description

A cyclic analog of L-glutamate; binds to GluK1, GluK2, GluK3, GluK4, and GluK5 (Kis = 75.9, 12.7, 32.8, 4.7, and 15 nM, respectively); induces calcium influx and membrane depolarization, as well as glutamate release, in rat brain synaptosomes at 5 mM; induces chromatin condensation and nuclear membrane fragmentation in primary neonatal cerebellar granule neurons at 100 µM; induces convulsive behavior in rats (ED50 = 0.51 nmol/animal) and induces seizures in mice (CD50 = 0.39 nmol/animal); has been commonly used to induce seizures in rodents

Formal name: 2S-carboxy-4S-(1-methylethenyl)-3S-pyrrolidineacetic acid, monohydrate

Synonyms: 

Molecular weight: 231.2

CAS: 58002-62-3

Purity: ≥98%

Formulation: A crystalline solid

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