Description
An insecticide and GABAA receptor antagonist; inhibits GABA-stimulated chloride uptake by membrane vesicles from rat cerebral cortex (IC50 = 68 μM); binds selectively to insect GABAA receptors over mammalian GABAA receptors in membrane preparations (IC50s = 1, 12, 505, 833, 150-1, 675 nM for fruit fly, house fly, human, mouse, and rat, respectively); a human recombinant β3 homooligomer with similar selectivity as α1β3γ2-containing receptors, indicating that the binding site for γ-lindane on GABAA receptors is located on the β3 subunit (IC50s = 0.90, 21, and 306 nM for β3, α1β3γ2, and the native receptor, respectively); blocks GABA- and glutamate-induced current responses in American cockroach neurons (IC50s = 1.74 and 148 nM, respectively); toxic to mice and adult house flies (LD50s = 40 and 5.5 mg/kg, respectively); kills head lice in vitro and inhibits hatching
Formal name: 1α,2α,3β,4α,5α,6β-hexachloro-cyclohexane
Synonyms:
Molecular weight: 290.8
CAS: 58-89-9
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Neuroscience
