Description
β-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway.{14334,14336} The role of β-catenin in these processes is thought to be regulated by the sequential phosphorylation of Ser29, Ser33, Ser37, and Thr41 by glycogen synthase kinase 3β (GSK3β).{14335} This hyperphosphorylation promotes the ubiquitylation and targeted destruction of β-catenin. Mutations in components of this phosphorylation-regulated process that prevent β-catenin hyperphosphorylation by GSK3β are strongly associated with cancers.{14335,14336,14337}
Synonyms: Anti-Phospho-Ser33,37 β-Catenin
Immunogen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human .beta.-catenin
Formulation: Affinity-purified IgG
Isotype:
Applications: WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|ECM & Adhesion Molecules
