A pentacyclic triterpene with diverse bioactivities; inhibits 5-LO (IC50 = ~5 µM); inhibits cell proliferation in HL-60 cells (IC50s = 3.7

β-Boswellic Acid – 1 mg

Brand:
Cayman
CAS:
631-69-6
Storage:
-20
UN-No:
Non-Hazardous - /

β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities.{30044} It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 µM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid (Item No. 11672).{6066} It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 µM for DNA, RNA, and protein synthesis, respectively.{38153} In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS).{38155} It also increases calcium mobilization in platelets at concentrations ≥3 µM and induces platelet aggregation (EC50 = 8 µM).{38154}  

 

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SKU: 11693 - 1 mg Category:

Description

A pentacyclic triterpene with diverse bioactivities; inhibits 5-LO (IC50 = ~5 µM); inhibits cell proliferation in HL-60 cells (IC50s = 3.7, 7.1, and 6.3 µM for DNA, RNA, and protein synthesis, respectively); increases nitric oxide and phosphorylation of eNOS in HUVECs deprived of oxygen and glucose; increases calcium mobilization in platelets (≥3 µM); induces platelet aggregation (EC50 = 8 µM),

Formal name: (3α,4β)-3-hydroxy-urs-12-en-23-oic acid

Synonyms: 

Molecular weight: 456.7

CAS: 631-69-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Prenol Lipids||Research Area|Cancer||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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