An active metabolite of α-zearalenol that acts as an ER agonist; inhibits [3H]estradiol binding to estrogen receptors on calf uterus in a dose-dependent manner; increases endometrial thickness

α-Zearalanol – 5 mg

Brand:
Cayman
CAS:
26538-44-3
Storage:
-20
UN-No:
Non-Hazardous - /

α-Zearalanol is an active metabolite formed by reduction of α-zearalenol (Item No. 16549), an estrogen receptor antagonist.{27392} α-Zearalanol inhibits [3H]estradiol binding to estrogen receptors (ERs) on calf uterus in a dose-dependent manner. Dietary α-zearalanol (10 mg/kg per day) increases endometrial thickness, bone mineral density, and serum levels of alkaline phosphatase in ovariectomized rats.{35165} It also decreases sperm count and motility and serum levels of testosterone (Item Nos. 15645 | ISO60154), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) in male mice.{35167}  

 

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SKU: 23424 - 5 mg Category:

Description

An active metabolite of α-zearalenol that acts as an ER agonist; inhibits [3H]estradiol binding to estrogen receptors on calf uterus in a dose-dependent manner; increases endometrial thickness, bone mineral density, and serum levels of alkaline phosphatase in ovariectomized rats at a dose of 10 mg/kg per day; decreases sperm count and motility and serum levels of testosterone, FSH, and LH in male mice,

Formal name: (3S,7R)-3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one

Synonyms:  (-)-α-Zearalanol|MK-188

Molecular weight: 322.4

CAS: 26538-44-3

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Toxicology|Drug Metabolism|Drug Metabolites||Research Area|Toxicology|Environmental|Endocrine Disruption

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