Immunogen: Phosphopeptide corresponding to amino acid residues surrounding phospho-Ser129 of rat α-synuclein • Host: Rabbit • Species Reactivity: (+) Human

α-Synuclein (Phospho-Ser129) Polyclonal Antibody – 100 µl

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Cayman
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α-Synuclein is a 140-amino acid intracellular protein encoded by the SNCA gene in humans.{46939} It is primarily localized to the synaptic terminal of neurons in both the central and peripheral nervous systems where it has a role in regulation of synaptic vesicle docking and neurotransmitter release.{46938} α-Synuclein is an intrinsically disordered, multi-domain protein.{46939,46937} It exists as monomer in the cytoplasm, however, mutations, posttranslational modifications, and changes in cellular environmental conditions can induce oligomerization and aggregate formation that lead to various pathologies, including Parkinson’s disease, Lewy body disease, multiple system atrophy (MSA), and amyotrophic lateral sclerosis (ALS). Phosphorylation of α-synuclein at serine 129 (Ser129) is increased in response to mitochondrial stress and is reduced by lysosome inhibition in SH-SY5Y cells.{46941} It enhances α-synuclein-induced neurotoxicity in Drosophila and rat models of Parkinson’s disease.{46942,46941} Levels of phosphorylated Ser129 (phospho-Ser129) are increased in Lewy bodies in postmortem brains from patients with Parkinson’s disease and Lewy body disease compared with control individuals.{46942,46940,46941} Cayman’s α-Synuclein (Phospho-Ser129) Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes α-synuclein (phospho-Ser129) at approximately 15 kDa from human, mouse, and rat samples.  

 

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SKU: 29252 - 100 µl Category:

Description

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding phospho-Ser129 of rat α-synuclein • Host: Rabbit • Species Reactivity: (+) Human, Mouse, Rat • Applications: IHC and WB • MW = ~15 kDa

Synonyms: SNCA|α-Syn

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding phospho-Ser129 of rat α-synuclein

Formulation: 100 µl of Affinity-purified rabbit polyclonal antibody

Isotype:

Applications: IHC and WB

Origin:

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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