A 5-HT receptor agonist; binds selectively to 5-HT1A

α-methyl Serotonin (maleate) – 25 mg

Brand:
Cayman
CAS:
97469-12-0
Storage:
-20
UN-No:
Non-Hazardous - /

α-methyl Serotonin is an agonist of serotonin (5-HT) receptors.{47638,47647} It binds selectively to 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT1D receptors over 5-HT1E receptors (Kis = 42, 85, 150, 150, and >10,000 nM, respectively).{47638} It is also selective for 5-HT2B and 5-HT2C receptors over 5-HT2A receptors (EC50s = 2.98, 50.1, and 794 nM, respectively).{47647} α-methyl Serotonin (30 μM) potentiates motor neuron depolarizations induced by NMDA (Item No. 14581) in the presence of the NMDA receptor antagonist memantine (Item No. 14184) in R. pipiens (frog) spinal cord ex vivo.{47648} It also increases dopamine release from rat striatum in vivo in a dose-dependent manner.{47649} α-methyl Serotonin (64 μg/kg) increases systolic blood pressure and transiently increases heart rate in conscious dogs.{47650}  

 

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Description

A 5-HT receptor agonist; binds selectively to 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT1D receptors over 5-HT1E receptors (Kis = 42, 85, 150, 150, and >10,000 nM, respectively); selective for 5-HT2B and 5-HT2C receptors over 5-HT2A receptors (EC50s = 2.98, 50.1, and 794 nM, respectively); potentiates NMDA-induced motor neuron depolarizations in the presence of the NMDA receptor antagonist memantine in R. pipiens (frog) spinal cord ex vivo at 30 μM; increases dopamine release from rat striatum in vivo in a dose-dependent manner; increases systolic blood pressure and transiently increases heart rate in conscious dogs at 64 μg/kg

Formal name: 3-(2-aminopropyl)-1H-indol-5-ol, (2Z)-2-butenedioate

Synonyms:  α-Me-5-HT|α-Methyl-5-HT|α-Methyl-5-hydroxytryptamine|α-Methylserotonin

Molecular weight: 306.3

CAS: 97469-12-0

Purity: ≥98%

Formulation: A solid

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