An α-hydroxy acid; levels are increased in 2-hydroxyglutaric aciduria; can be metabolized from isocitrate by mutated forms of IDH1 and IDH2; competitively inhibits α-ketoglutarate-dependent dioxygenases

α-Hydroxyglutaric Acid (sodium salt) – 25 mg

Brand:
Cayman
CAS:
40951-21-1
Storage:
-20
UN-No:
Non-Hazardous - /

α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid (Item No. 21123).{26770,26771,26772} 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2.{26773,26775} 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.{26775,26774,26769}  

 

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Description

An α-hydroxy acid; levels are increased in 2-hydroxyglutaric aciduria; can be metabolized from isocitrate by mutated forms of IDH1 and IDH2; competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases

Formal name: 2-hydroxy-pentanedioic acid, disodium salt

Synonyms:  2-HG|2-Hydroxyglutaric Acid

Molecular weight: 192.1

CAS: 40951-21-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Fatty Acids||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Lipid Biochemistry||Research Area|Neuroscience

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