A triterpenoid saponin with diverse biological activities; increases spontaneous motoric activity in isolated rat stomach corpus and fundus strips from 25 to 320 μM; cytotoxic to J82

α-Hederin – 5 mg

Brand:
Cayman
CAS:
27013-91-8
Storage:
-20
UN-No:
Non-Hazardous - /

α-Hederin is a triterpenoid saponin that has been found in K. pictus and has diverse biological activities.{51169,51166,51167,51168} It increases spontaneous motoric activity in isolated rat stomach corpus and fundus strips when used at concentrations ranging from 25 to 320 μM.{51169} It is cytotoxic to J82 and T24 human bladder carcinoma, Colon26 murine colon adenocarcinoma, and 3LL Lewis murine lung carcinoma cells (EC50s = 15.5, 16.5, 12.5, and 1.1 μM, respectively).{51166} α-Hederin (7.5 and 15 mg/kg) increases survival time in a 3LL Lewis mouse lung carcinoma model. It reduces acetic acid-induced writhing in mice when administered at doses of 10 and 20 mg/kg.{51167} α-Hederin (5, 10, and 20 mg/kg) reduces paw edema in a rat model of rheumatoid arthritis induced by Freund’s complete adjuvant (FCA). It dose-dependently prevents carbon tetrachloride-induced increases in serum alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activity, as well as hepatic levels of malondialdehyde (MDA) in a mouse model of hepatic injury.{51168} α-Hederin also decreases levels of the cytochrome P450 (CYP) isoform CYP2E1 in mouse liver.  

 

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Description

A triterpenoid saponin with diverse biological activities; increases spontaneous motoric activity in isolated rat stomach corpus and fundus strips from 25 to 320 μM; cytotoxic to J82, T24, Colon26, and 3LL Lewis cells (EC50s = 15.5, 16.5, 12.5, and 1.1 μM, respectively); increases survival time in a 3LL Lewis mouse lung carcinoma model at 7.5 and 15 mg/kg; reduces acetic acid-induced writhing in mice at 10 and 20 mg/kg; reduces paw edema in a rat model of rheumatoid arthritis induced by FCA; prevents carbon tetrachloride-induced increases in serum ALT and LDH activity as well as hepatic levels of MDA in a mouse model of hepatic injury; decreases levels of CYP2E1 in mouse liver

Formal name: (3β,4α)-3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-olean-12-en-28-oic acid

Synonyms:  Kalopanaxsaponin A|Koronaroside A|NSC 106553

Molecular weight: 751

CAS: 27013-91-8

Purity: ≥98%

Formulation: A crystalline solid

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