Description
α-Cardiac actin is one of the main actin isoforms found in adult cardiac muscle and the predominant actin in the embryonic heart.{60039,60040} It is a globular protein that forms microfilaments at the Z-disc of sarcomeres and interacts with myosin to perform myofilament, and thus cardiac muscle, contractions.{60041} Knockout of Actc1, the gene encoding α-cardiac actin, is embryonic lethal in approximately half of mice and generally lethal within two weeks of birth for the other 50%.{60039} Mutations in ACTC1 are associated with atrial septal defects, familial hypertrophic cardiomyopathy, and idiopathic dilated cardiomyopathy.{60040,60042} Cayman’s α-Cardiac Actin (N-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Synonyms: ACTC1|Actin|alpha Cardiac Muscle 1
Immunogen: Synthetic peptide corresponding to the N-terminal region of human α-cardiac actin
Formulation: 100 µl of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: IHC, WB
Origin:
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cardiovascular System|Cardiovascular Diseases|Cardiomyopathy||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy
