A sesquiterpene alcohol with diverse biological activities; inhibits the growth of L. amazonensis promastigotes and amastigotes (IC50s = 8.07 and 4.29 μg/ml

(–)-α-Bisabolol – 1 mg

Brand:
Cayman
CAS:
23089-26-1
Storage:
-20
UN-No:
De Minimis - 3082 / 9

(–)-α-Bisabolol is a sesquiterpene alcohol that has been found in the essential oils of several aromatic plants, including C. sativa, C. indica, and C. sativa/C. indica hybrid strains, with diverse biological activities.{42303,42347,42348,42349,42350} It inhibits the growth of L. amazonensis promastigotes and amastigotes (IC50s = 8.07 and 4.29 μg/ml, respectively).{42347} It also reduces the growth of L. infantum and L. donovani amastigotes (IC50s = 56.9 and 39.4 μM, respectively) with a cytotoxic concentration (CC50) value of greater than 1,000 μM in L929 cells.{42348} In vivo, (–)-α-bisabolol (200 mg/kg) reduces parasite load in the liver and spleen in a mouse model of visceral leishmaniasis. (–)-α-Bisabolol (200 mg/kg) reduces the size of ethanol-induced lesions, decreases malondialdehyde (MDA) production, and increases superoxide dismutase (SOD) activity in gastric mucosa in mice.{42349} It also decreases serotonin-, carrageenan-, and dextran-, but not histamine-, induced paw edema as well as acetic-acid induced writhing and paw-licking time in the formalin test in mice, indicating anti-inflammatory and antinociceptive activity.{42350}  

 

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SKU: 9002495 - 1 mg Category:

Description

A sesquiterpene alcohol with diverse biological activities; inhibits the growth of L. amazonensis promastigotes and amastigotes (IC50s = 8.07 and 4.29 μg/ml, respectively); reduces the growth of L. infantum and L. donovani amastigotes (IC50s = 56.9 and 39.4 μM, respectively) without inducing cytotoxicity in L929 cells (CC50 = greater than 1,000 μM); reduces parasite load in the liver and spleen in a mouse model of visceral leishmaniasis at 200 mg/kg; reduces the size of ethanol-induced lesions, decreases MDA production, and increases SOD activity in gastric mucosa in mice at 200 mg/kg; decreases serotonin-, carrageenan-, and dextran-, but not histamine-, induced paw edema as well as acetic-acid induced writhing and paw-licking time in the formalin test in mice,

Formal name: (αS,1S)-α,4-dimethyl-α-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-methanol

Synonyms: 

Molecular weight: 222.4

CAS: 23089-26-1

Purity: ≥90%

Formulation: A liquid

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