A racemic version of a CYP450 pathway metabolite of arachidonic acid; can be used to quantify 5(6)-EET; activates BK channels in smooth muscle cells from rat small coronary arteries; a substrate for sheep seminal vesicle COX; plasma levels decrease in a high-fat diet-induced rat model of hyperlipidemia

(±)5(6)-DiHET – 50 µg

Brand:
Cayman
CAS:
213382-49-1
Storage:
-20
UN-No:
De Minimis - 1170 / 3

5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET (Item Nos. 50211 | 10007260) by epoxide hydrolases.{729} 5(6)-DiHET can be used to quantify 5(6)-EET due to the conversion of 5(6)-EET to 5(6)-δ-lactone in solution.{39654} 5(6)-DiHET activates large conductance calcium-activated potassium (BK) channels in smooth muscle cells from rat small coronary arteries.{37444} It is a substrate for sheep seminal vesicle COX, producing 5,6-dihydroxy prostaglandin E1 and F1α metabolites in vitro.{461} 5(6)-DiHET levels decrease in plasma in a high-fat diet-induced rat model of hyperlipidemia.{37445}  

 

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Description

A racemic version of a CYP450 pathway metabolite of arachidonic acid; can be used to quantify 5(6)-EET; activates BK channels in smooth muscle cells from rat small coronary arteries; a substrate for sheep seminal vesicle COX; plasma levels decrease in a high-fat diet-induced rat model of hyperlipidemia

Formal name: (±)5,6-dihydroxy-8Z,11Z,14Z-eicosatrienoic acid

Synonyms:  (±)5,6-DiHETrE

Molecular weight: 338.5

CAS: 213382-49-1

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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