(±)14-HDHA is an autoxidation product of DHA in vitro.{7479

(±)14-HDHA – 250 µg

Brand:
Cayman
CAS:
87042-40-8
Storage:
-20
UN-No:
De Minimis - 1170 / 3

(±)14-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.{7479,7491} It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.{7480,7490,7492} DHA is metabolized to 14(S)-HDHA by human platelets along with 11(S)-HDHA.{7483,7484,7492} 14(S)-HDoHE is also produced by salmon gills upon stimulation with calcium ionophore.{7514} 14(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 70, 3.6, and 5.3 µM, respectively.{7484,7481} (±)14-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.  

 

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Description

(±)14-HDHA is an autoxidation product of DHA in vitro.{7479,7491} It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.{7480,7490,7492} DHA is metabolized to 14(S)-HDHA by human platelets along with 11(S)-HDHA.{7483,7484,7492} 14(S)-HDHA is also produced by salmon gills upon stimulation with calcium ionophore.{7514} 14(S)-HDHA is an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 70, 3.6, and 5.3 µM, respectively.{7484,7481} (±)14-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.

Formal name: (±)14-hydroxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid

Synonyms:  (±)14-HDoHE|14-hydroxy Docosahexaenoic Acid

Molecular weight: 344.5

CAS: 87042-40-8

Purity: ≥98%

Formulation: A solution in ethanol

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